- Rowland Kao
Institute of Biodiversity Animal Health and Comparative Medicine,
University of Glasgow, UK.
Title: The contribution of phylodynamics to understanding multi-scale infection processes on networks.
Abstract: Phylodynamics is the nascent field where the aim is to understand how epidemiological, immunological, and evolutionary processes act and potentially interact to shape pathogen phylogenies. The acceleration of research in this field has hinged on recent technological developments, of which the most important is the application of next generation sequencing technology to generate large datasets describing pathogen phylogenies with unprecedented detail. Using examples from livestock diseases, in particular bovine Tuberculosis in cattle and badgers, in this talk I shall show how integration with similarly dense denominator datasets has led to an improved understanding of how the process of disease transmission, represented by the phylogeny, is driven by the pattern of underlying contact heterogeneity.
- Jacco Wallinga
Centre for Infectious Disease Control, National Institute of Public Health
and the Environment (RIVM), The Netherlands.
Title: Transmission networks from sequence data.
Abstract: Traditionally the analysis of infectious disease data has focused on case notification data (“place, person, time”). Now the increasing availability of genetic sequence data allows us to incorporate that high-dimensional data (“place, person, time, type”). This might allow us to better estimate key variables from outbreak data, such as transmission potential and generation interval. More importantly, this enables us to infer features of transmission that could not be estimated before. Here we discuss our recent findings with respect to testing for the effect of local co-variates on transmission intensity, and detecting the structure of the contact network for influenza A H7N7 outbreaks.